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Rabbit Anti-NIS/BF594 Conjugated antibody (bs-0448R-BF594)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0448R-BF594
英文名稱1 Rabbit Anti-NIS/BF594 Conjugated antibody
中文名稱 BF594標記的鈉碘轉運體蛋白抗體
別    名 Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na+/I- cotransporter; Na+/I-symporter; NIS; SC5A5_HUMAN; SLC5A5; sodium iodide symporter; Sodium-iodide symporter; Sodium/iodide cotransporter; Solute carrier family 5 (sodium iodide symporter) member 5; Solute carrier family 5; Solute carrier family 5 member 5.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 免疫學  通道蛋白  轉運蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 68kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human NIS C-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
catalyzes Na+/I- symporter activity plays a role in iodide transport and thyroid hormone generation.
Human Sodium Iodide Symporter (hNIS) is responsible for iodide concentrating ability within thyroid follicular cells. It is a membrane bound glycoprotein with 13 membrane spanning domains and 14 extramembranous domains. It may represent an autoantigen in thyroid.

Function:
Mediates iodide uptake in the thyroid gland.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.

DISEASE:
Thyroid dyshormonogenesis 1 (TDH1) [MIM:274400]: A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.

Database links:

Entrez Gene: 6528 Human

Entrez Gene: 114613 Rat

Omim: 601843 Human

SwissProt: Q92911 Human

SwissProt: Q63008 Rat

Unigene: 103983 Human

Unigene: 584804 Human

Unigene: 10505 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

鈉/碘轉運體蛋白-NIS,是位于甲狀腺細胞基底膜上的一類膜抗原,在甲狀腺對碘的主動轉運過程中發揮重要作用。
鈉/碘轉運蛋白受甲狀腺刺激素(TSH)、碘、細胞因子和生長因子等多種因素的廣泛調節。自身免疫性甲狀腺疾病時NIS的表達發生了明顯變化,患者體內出現抗NIS自身抗體。
此外,NIS還與甲狀腺冷結節和先天性甲狀腺機能減退等甲狀腺疾病的發病機理密切相關,近年來得到了足夠的重視。
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