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Rabbit Anti-E cadherin  antibody (bs-1519R)  
~~~促銷代碼KT202411~~~
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產品編號 bs-1519R
英文名稱 Rabbit Anti-E cadherin  antibody
中文名稱 上皮鈣粘附分子抗體
別    名 E-cadherin; anion exchanger protein 3; Arc 1; Cadherin 1; cadherin 1 type 1 E-cadherin; Cadherin1; CAM 120/80; CD 234; CD324; CD324 antigen; CDH1; CDHE; ECAD; Epithelial cadherin; epithelial calcium dependant adhesion protein; LCAM; Liver cell adhesion molecule; UVO; Uvomorulin; CADH1_HUMAN.  
Specific References  (27)     |     bs-1519R has been referenced in 27 publications.
[IF=17.521] Zhongjie Tang. et al. Overcoming the On-Target Toxicity in Antibody-Mediated Therapies via an Indirect Active Targeting Strategy. Advanced Science. 2023 Jan;:2206912  WB ;  Mouse.  
[IF=11.161] Zhipeng Jiang. et al. EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway. J Exp Clin Canc Res. 2021 Dec;40(1):1-15  WB,IHC ;  Human.  
[IF=9.584] Zheng, Bingxin. et al. Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway. CELL BIOSCI. 2022 Dec;12(1):1-15  WB ;  Human.  
[IF=6.986] Wu Ya-xian. et al. 4-OI ameliorates bleomycin-induced pulmonary fibrosis by activating Nrf2 and suppressing macrophage-mediated epithelial-mesenchymal transition. INFLAMM RES. 2023 May;:1-13  IHC,WB ;  Mouse.  
[IF=6.73] Yue, Huan. et al. LINC02154 promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing SPC24 promoter activity and activating the PI3K-AKT signaling pathway. CELL ONCOL. 2022 May;:1-16  WB ;  Human,Mouse.  
[IF=6.543] Yang Lili. et al. Elucidating the Novel Mechanism of Ligustrazine in Preventing Postoperative Peritoneal Adhesion Formation. Oxid Med Cell Longev. 2022;2022:9226022  WB,IF ;  Rat,Human.  
[IF=6.491] Nikhil K et al. Identification of LIMK2 as a Therapeutic Target in Castration Resistant Prostate Cancer. Cancer Lett. 2019 Apr 28;448:182-196.  WB&IHC ;  Mouse.  
[IF=6.388] Yu-jie Lu. et al. Ligustilide attenuates airway remodeling in COPD mice by covalently binding to MH2 domain of Smad3 in pulmonary epithelium, disrupting the Smad3-SARA interaction. PHYTOTHER RES. 2022 Oct;:  IHC, WB ;  Mouse,Human.  
[IF=6.244] Pei Dai. et al. Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR. Front Oncol. 2021; 11: 699847  WB ;  Human.  
[IF=6.208] Yang Liu. et al. Role of Autotaxin in High Glucose-Induced Human ARPE-19 Cells. INT J MOL SCI. 2022 Jan;23(16):9181  ICC ;  Human.  
[IF=5.81] Zhou Z. et al. Vanillin Derivatives Reverse Fusobacterium nucleatum-Induced Proliferation and Migration of Colorectal Cancer Through E-Cadherin/β-Catenin Pathway.. Front Pharmacol. 2022 Mar;13:841918-841918  WB ;  Human.  
[IF=5.195] Yunhao Ma. et al. CFNC, a neocryptolepine derivative, inhibited the growth of gastric cancer AGS cells by inhibiting PI3K/AKT signaling pathway. EUR J PHARMACOL. 2023 Jan;938:175408  WB ;  Human.  
[IF=4.784] Zheng Wu. et al. FOXD3 suppresses epithelial–mesenchymal transition through direct transcriptional promotion of SMAD7 in esophageal squamous cell carcinoma. 2021 Sep 22  WB ;  human.  
[IF=4.175] Junmin Li. et al. Circ_ZFR contributes to the paclitaxel resistance and progression of non-small cell lung cancer by upregulating KPNA4 through sponging miR-195-5p. Cancer Cell Int. 2021 Dec;21(1):1-15  WB ;  
[IF=4.175] Huajun Wang. et al. LncRNA NEAT1 promotes proliferation, migration, invasion and epithelial-mesenchymal transition process in TGF-β2-stimulated lens epithelial cells through regulating the miR-486-5p/SMAD4 axis. Cancer Cell Int. 2020 Dec;20(1):1-12  WB ;  Human.  
[IF=4.068] Hao Cui. et al. Mena as a key enhancer factor of EMT to promote metastasis of human tongue squamous cell carcinoma. ORAL DIS. 2023 May;:  WB ;  Human.  
[IF=3.7] Wang et al. Expression and clinical significance of autophagic protein LC3B and EMT markers in gastric cancer. (2018) Cancer.Manag.Res. 10:1479-1486  IHC ;  Human.  
[IF=3.481] Jinzhu Han. et al. Circ_0027599 elevates RUNX1 expression via sponging miR-21-5p on gastric cancer progression. 2021 May 25  WB ;  Human.  
[IF=3.405] Wu Y et al. MFAP5 promotes basal-like breast cancer progression by activating the EMT program.Cell Biosci. 2019 Mar 7;9:24.  WB ;  Human.  
[IF=3.333] Liu SQ et al. Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial?mesenchymal transition mediated by the FAK/AKT/MMPs axis.Int. J. Oncol. 2018 Oct 25  IHC ;  Human.  
[IF=3.192] Dr. Jing Tian. et al. Downregulation of SOX21-AS1 alleviated cisplatin resistance in cervical cancer through Epithelial-messenchymal transition (EMT) inhibition. REJUV RES. 2022 Aug 30  IF, IHC ;  Human, Mouse.  
[IF=3.111] Qi Rao. et al. Effects of dihydroartemisinin combined with cisplatin on proliferation, apoptosis and migration of HepG2 cells. ONCOL LETT. 2022 Aug;24(2):1-9  WB ;  Human.  
[IF=2.826] Yingmin Liu. et al. LOXL2 promotes tumor proliferation and metastasis by FAK/Src signaling in esophageal squamous cell carcinoma. ELECTRON J BIOTECHN. 2023 Apr;:  WB ;  Human.  
[IF=2.344] Zhu, Ting. et al. Irisin/FNDC5 inhibits the epithelial–mesenchymal transition of epithelial ovarian cancer cells via the PI3K/Akt pathway. Arch Gynecol Obstet. 2022 Feb;:1-10  WB ;  Human.  
[IF=2.15] Fan, Hai-Xia, et al. "Sonic hedgehog signaling may promote invasion and metastasis of oral squamous cell carcinoma by activating MMP-9 and E-cadherin expression." Medical Oncology 31.7 (2014): 1-8.  IHC-P ;  Human.  
[IF=1.977] Qinhong Xu. et al. Overexpression of circ_0001445 decelerates hepatocellular carcinoma progression by regulating miR-942-5p/ALX4 axis. Biotechnol Lett. 2020 Dec;42(12):2735-2747  WB ;  Human.  
[IF=1.61] Yu, Yang, et al. "RNA interference-mediated knockdown of Notch-1 inhibits migration and invasion, down-regulates matrix metalloproteinases and suppresses NF-κB signaling pathway in trophoblast cells." Acta Histochemica (2014).  WB ;  Human.  
研究領域 腫瘤  細胞生物  免疫學  細胞粘附分子  細胞表面分子  上皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human (predicted: Mouse,Rat,Pig,Cow,Chicken,Dog,Horse)
產品應用 WB=1:500-2000,Flow-Cyt=1μg/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
細胞定位 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human E-cadherin: 841-882/882 <Cytoplasmic>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

Function:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.
E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.

Subunit:
Homodimer.

Subcellular Location:
Cell junction. Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Non-neural epithelial tissues.

Post-translational modifications:
During apoptosis or with calcium influx, cleaved by a membrane-bound metalloproteinase (ADAM10), PS1/gamma-secretase and caspase-3 to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. Processing by the metalloproteinase, induced by calcium influx, causes disruption of cell-cell adhesion and the subsequent release of beta-catenin into the cytoplasm. The residual membrane-tethered cleavage product is rapidly degraded via an intracellular proteolytic pathway. Cleavage by caspase-3 releases the cytoplasmic tail resulting in disintegration of the actin microfilament system. The gamma-secretase-mediated cleavage promotes disaaaembly of adherens junctions.

DISEASE:
Defects in CDH1 are involved in dysfunction of the cell-cell adhesion system, triggering cancer invasion (gastric, breast, ovary, endometrium and thyroid) and metastasis.
Defects in CDH1 are a cause of gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer (HDGC).
Defects in CDH1 are a cause of susceptibility to endometrial cancer [MIM:608089].
Defects in CDH1 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome.

Similarity:
Contains 5 cadherin domains.

SWISS:
P12830

Gene ID:
999

Database links:

Entrez Gene: 999 Human

Entrez Gene: 12550 Mouse

Entrez Gene: 83502 Rat

Omim: 192090 Human

SwissProt: P12830 Human

SwissProt: P09803 Mouse

SwissProt: Q9R0T4 Rat

Unigene: 461086 Human

Unigene: 35605 Mouse

Unigene: 1303 Rat



細胞粘附蛋白（Call Adhesion Protein）
E-chaherin是研究較多的同質粘附分子。E-cadherin的表達與惡性腫瘤的分化程度、侵襲力、轉移負相關與預后正相關，E-cadherin的低表達和不穩定表達可促進轉移的發生。近年來已成為腫瘤細胞侵襲和轉移研究的熱點之一。
產品圖片
Sample: Lane 1: MDA-MB-231 (Human) Cell Lysate at 30 ug Lane 2: A431 (Human) Cell Lysate at 30 ug Lane 3: A549 (Human) Cell Lysate at 30 ug Lane 4: HepG2 (Human) Cell Lysate at 30 ug Primary: Anti- E cadherin (bs-1519R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 125 kD Observed band size: 120 kD
Histogram of MCF7 cells stained with anti-E-cadherin (orange), isotype control antibody (green), secondary antibody only (blue) and unstained (red).
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